Alterations in Serum Globulins during T H E Formation and Resorption of Amyloid in Rabbits* by Goetz

For example, it has been found that the serum protein patterns of patients suffering from amyloidosis are often abnormal (1-4), that abnormal serum globulins and amyloid may both be present in patients with multiple myeloma (5-7), and that the incidence of amyloidosis is high in hyperlmmunized horses (8). Yet no single abnormality of the blood proteins has thus far been clearly related to amyloidosis; indeed, the electrophoretic patterns of serum proteins from patients with advanced amyloidosis are variable (1-4). Hence there is reason to question whether abnormalities of the circulating proteins play a part in the pathogenesis of the disease. More evidence on this point has been sought in the present study.